What Does Clomid Do for Men?

So what does clomid do for men? Let’s explore how it works and the targeted treatment you should know more about. 

Clomid was originally used to treat infertility in women, but in recent years physicians have been using clomid off-label to treat low testosterone in men. 

Clomid contains two isomers: enclomiphene and zuclomiphene. But only one of them—enclomiphene—actively supports testosterone production. Zuclomiphene is often thought to work against this process.

For men seeking low testosterone treatment outside of TRT, clomid is a decent option, however you should know that enclomiphene proves to be a potentially more powerful treatment. 

In this article we’ll explore what clomid does for men, how it stimulates testosterone production, and what targeted treatment you should consider. 

How Clomid Works in Men

So what does clomid do for men? 

Clomid belongs to a class of medications called Selective Estrogen Receptor Modulators (SERMs). This type of medication signals to your body that estrogen levels are low, which leads to an increase in two key hormones: luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Those hormones do the real work. 

LH tells your testicles to produce more testosterone, while FSH supports sperm production. 

The ideal result is a boost in natural testosterone levels without shutting down your body's own hormone production pathways—the way traditional testosterone replacement therapy (TRT) often does.

This mechanism is exactly why Clomid is often used in younger men or those trying to preserve fertility. It stimulates your body to do the work itself, instead of relying on an outside source of testosterone.

What’s Actually in Clomid? Two Isomers, One That Matters

Clomid is made up of two isomers: enclomiphene and zuclomiphene.

• Enclomiphene is the active isomer responsible for increasing testosterone.
  
  
• Zuclomiphene, on the other hand, is considered inactive, or in some cases, counterproductive. It can linger in the body longer and has been associated with more side effects, including mood swings, visual disturbances, and estrogen-like effects in some men.

In short, only half of Clomid is doing what you actually want it to do. And the other half? It may be getting in the way.

This is a key reason why many physicians now consider isolated enclomiphene a cleaner, more effective option for men looking to boost testosterone without the baggage.

Enclomiphene May Be 445% More Effective Than Clomid (according to studies)

Clinical research reveals a striking difference between Clomid and its active component, enclomiphene. 

While Clomid contains both enclomiphene and zuclomiphene, enclomiphene alone delivers significantly stronger results.

In fact, studies show that enclomiphene increases testosterone levels up to 445% more effectively than Clomid. 

To put that into perspective:

• Men treated with enclomiphene saw testosterone levels rise by as much as 674% from baseline.
  
  
• Those taking Clomid experienced a more modest increase of about 229%.

This nearly threefold difference can be the deciding factor between a mild improvement and a life-changing boost in energy, mood, and vitality.

Because enclomiphene targets testosterone production more precisely (without the counteractive effects of zuclomiphene) it offers a more predictable treatment experience.

While Clomid remains widely used and effective for many men, it’s important to know that some patients may experience inconsistent results or side effects due to its dual-isomer composition. For these men, isolated enclomiphene can offer a more targeted and predictable alternative.

The Bottom Line: What Does Clomid Do for Men?

Clomid works by stimulating your body’s own hormone system to increase testosterone production—offering a fertility-friendly alternative to traditional testosterone replacement therapy. It contains two compounds, but only one, enclomiphene, actively boosts testosterone.

While Clomid can be effective for some men, clinical research shows that enclomiphene alone is up to 445% more effective, providing stronger, more consistent testosterone increases with fewer side effects.

If you’re considering treatment for low testosterone and want results that preserve fertility without the unpredictable side effects of Clomid, enclomiphene is worth a closer look.

What Should You Do Next?

At Strut Health, we specialize in prescribing enclomiphene through our product Strut Mojo, which supports natural testosterone production—and can be combined with tadalafil to address sexual performance as well.

Complete our brief, confidential medical questionnaire to see if enclomiphene treatment is right for you. Our physicians will create a personalized plan and deliver your medication discreetly to your door.