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Clindamycin & Tretinoin: An Effective Anti-Acne Treatment

Wondering if the combination of clindamycin/tretinoin could finally clear your acne? Learn more about the benefits of clindamycin and tretinoin together for acne.

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Wondering if a clindamycin/tretinoin combination treatment could finally clear your acne? We've got you covered.

Acne affects up to 50 million Americans yearly. A whopping 85 percent of people between the ages of 18 and 24  deal with acne to some degree.

Even though it’s a very common skin condition, it can leave you feeling like the odd man out. You might have tried every acne wash and spot treatment known to man, but still deal with regular breakouts.

If that’s the case, it might be time to try prescription acne treatments. Now more than ever, it’s simple to obtain prescription anti-acne treatments online.  

You might consider trying clindamycin and tretinoin, proven effective prescription acne treatments. Keep scrolling to more about clindamycin and tretinoin for acne.

What is acne and why does it happen?

Acne Vulgaris is an incredibly common skin condition. Acne is often caused by bacteria or sebum overproduction which can cause pore blockages and inflammation.

Your pores can become clogged with dead skin cells, dirt, oil, product residue, and bacteria. Keeping your pores clear and getting acne-causing bacteria under control is essential when fighting acne.

Acne can range from mild to severe. Depending on the severity of acne, the treatments can vary.

Learn More: Mild, Moderate, and Severe Acne: How To Tell Acne Severity Levels

What is topical Clindamycin and how does it treat acne?

Clindamycin is a prescription topical antibiotic that combats the growth of acne-causing bacteria and reduces inflammation and swelling of the skin.

Clindamycin works well at reducing acne. In a 2013 study, after 8 weeks of treatment, participants experienced a significant reduction in inflammatory acne lesions while using a 1% clindamycin topical solution.

Studies show that clindamycin might work best in combination with other acne treatments such as tretinoin or benzoyl peroxide. According to the American Academy of Family Physicians clindamycin is part of the “first-line of treatment for moderate acne vulgaris.”

Tretinoin for acne

Tretinoin is a prescription retinoid often used to treat mild to moderate acne.

Retinoids are vitamin A derivatives and are powerful acne and anti-aging treatments. Tretinoin works well for acne because it increases skin cell turnover rate and decreases sebum production. As skin cell turnover speeds up, new skin cells are pushed to the surface, and the skin purges old skin cells, and trapped substances. Substances that once clogged pores are pushed out of the skin resulting in clearer skin.

Not only can retinoids like tretinoin clear out your pores, but they can also stop new breakouts from forming in the first place. Often, it takes 12 weeks of tretinoin treatment to see a visible reduction in acne.

Also Read: Strut Tretinoin Cream Online For Acne, Acne Scars, and Anti-Aging

How does a clindamycin/tretinoin compound solution treat acne?

The combination treatment of clindamycin and tretinoin is found to be a very effective acne treatment. The combination is more effective than monotherapies (stand-alone products).  

This is likely because this combination tackles pimples from all sides.

Clindamycin takes care of killing bacteria while tretinoin speeds up skin cell turnover rate. Both products help reduce inflammation.  


  • Speeds up skin cell turnover rate
  • Clears out pores
  • Stops pores from becoming clogged
  • Reduces inflammation
  • Increases collagen production


  • Reduces or stops the growth of acne-causing bacteria
  • Reduces inflammation and swelling

A 2019 study researching compound products containing both clindamycin and tretinoin showed continuous improvement in facial acne over 12 weeks.  Studies have shown that the combination of clindamycin and tretinoin was significantly more effective at treating acne than clindamycin gel alone.

Read Related: 3 Powerful Ingredients to Look for in Acne Scar Creams

Strut Health offers clindamycin with tretinoin acne treatments online

Strut Health has expertly formulated an anti-acne formula that targets breakouts from all sides.

Our formula combines tretinoin for increased skin cell turnover and decreased oil production, with topical antibiotic clindamycin which kills excess bacteria. We also include skin-loving B vitamins such as niacinamide to soothe your skin.

If you want to try our clindamycin and tretinoin compound acne treatment, complete a questionnaire-based online doctor's consultation. If our doctors find this acne formula is a good fit for you, we’ll ship your prescription to your doorstep.

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