Clomid vs Enclomiphene: Which is Best for Low Testosterone?

If you're researching low testosterone treatments, you've probably stumbled across the clomid vs enclomiphene debate. Here's the truth that might surprise you: one of these medications is a purified and targeted version of the other, and the difference could make or break your treatment experience.

The medical community has been moving toward enclomiphene more and more because it targets testosterone stimulation without the interfering effects of Clomid's secondary isomer compound.

If you're exploring smarter ways to boost your testosterone, let's clear up this clomid vs enclomiphene debate. 

Clomid vs Enclomiphene: What Are These Medications?

Both medications belong to a class called selective estrogen receptor modulators (SERMs). They work by blocking estrogen receptors in the brain, which tricks your body into producing more luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This increased hormone production naturally stimulates your testicles to produce more testosterone.

The key difference? 

Clomid is a mixture of two compounds (enclomiphene and zuclomiphene), while enclomiphene is the purified, active component that does the heavy lifting for testosterone stimulation. 

How They Work in Your Body

Here's the simple breakdown:

Clomid's Dual Action

Clomid contains both enclomiphene (about 62%) and zuclomiphene (about 38%). 

While enclomiphene stimulates testosterone production, zuclomiphene can actually work against this process and may cause unwanted side effects.

Enclomiphene's Targeted Approach

Enclomiphene is the isolated active ingredient that specifically targets testosterone production without the interfering side effects of zuclomiphene. This focused mechanism leads to more predictable results with fewer side effects.

Effectiveness: The Numbers Don't Lie

Clinical trials demonstrate that enclomiphene consistently raises testosterone levels more effectively than Clomid. 

In head-to-head comparisons:

Enclomiphene Results:

• Increased testosterone from 170 ng/dL to 1,144 ng/dL (674% increase)
• Mean testosterone increases ranging from 147-339 ng/dL above baseline
• Maintained normal LH and FSH levels
• Fertility parameters remained stable or improved
• Sustained results over 12+ months of treatment
• Comparative study also found a 8% reduction in serum cholesterol levels  

Clomid Results:

• Increased testosterone from 170 ng/dL to 559 ng/dL (229% increase)
• More variable and lower peak testosterone levels
• Less predictable hormone responses
• Higher discontinuation rates due to side effects
• More frequent dose adjustments needed

Adverse events occurred only 3.45% of the time with enclomiphene vs 18.18% with clomid.

The key difference: enclomiphene delivered nearly 3x the testosterone increase compared to Clomid in direct comparison studies.

5 Reasons Enclomiphene May Be The  Superior Choice

When comparing clomid vs enclomiphene head to head, it's clear the targeted profile of enclomiphene has a major edge. 

Here are 5 science-baked reasons you should consider enclomiphene vs clomid. 

1. Nearly 3x More Effective

In clinical studies, when both medications started from the same baseline testosterone level (170 ng/dL):

• Enclomiphene raised testosterone to 1,144 ng/dL
• Clomid only raised it to 559 ng/dL

That’s nearly 3x the increase with enclomiphene—often the difference between mild improvement and life-changing results.

2. Precision Medicine at Work

Enclomiphene is precise targeting. While Clomid forces your body to process both the active compound and its counterproductive partner, enclomiphene delivers only what you need for optimal testosterone production.

3. Better Tolerability for Long-Term Success

Enclomiphene's significantly lower side effect profile means men can maintain their therapy long-term without the quality of life disruptions that force many to abandon Clomid.

4. Fertility Preservation Without Compromise

When compared to TRT, enclomiphene maintains your body's natural hormone production pathways while delivering superior results. You get the testosterone optimization you need without sacrificing fertility—something increasingly important for men who want to start families.

5. Consistent, Predictable Results

The isolated compound eliminates the variability that often plagues Clomid treatment. Men experience more consistent testosterone elevation, fewer dose adjustments, and more predictable outcomes, making treatment planning and monitoring significantly easier.

Try Strut Mojo: Enclomiphene Done Right

Our physicians have seen the dramatic difference that isolating the right isomer makes for low testosterone patients. By choosing enclomiphene over Clomid's mixed formulation, Strut Mojo delivers the precise compound your body needs for optimal testosterone production—without the interference that limits results.

Because of its effects on fertility, traditional testosterone replacement therapy (TRT) is not our medical team’s  go-to treatment for men with low testosterone. 

Our team reaches for enclomiphene in this case. Available with or without tadalafil, Strut Mojo addresses both hormonal balance and sexual performance while preserving fertility—something increasingly important for men who want to start or expand their families.

Strut Mojo works with your body's natural systems to:

• Stimulate your own testosterone production using the isolated active isomer
• Maintain fertility while optimizing hormone levels
• Avoid the shutdown of natural hormone production that occurs with TRT
• Provide sustained results with minimal side effects
• Deliver the superior effectiveness our doctors have come to expect from enclomiphene

The Bottom Line: Clomid vs Enclomiphene

Clomid vs enclomiphene comparison reveals enclomiphene as the superior treatment for low testosterone. 

Clinical studies show enclomiphene as nearly 3x more effective than clomid. Enclomiphene 674% testosterone increase vs 229% testosterone increase on clomid.

Additionally seen in clinical studies, enclomiphene causes adverse events only 3.45% of the time compared to Clomid's 18.18% rate. 

As the isolated active compound, enclomiphene delivers targeted testosterone stimulation without zuclomiphene's interference, making it the preferred treatment for preserving male fertility while optimizing hormone levels.

Ready to experience the enclomiphene advantage?

Complete our brief medical questionnaire for Strut Mojo with enclomiphene to get a personalized treatment plan from our physicians, shipped discreetly to your door.