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What Is Stendra (Avanafil)? How Does This ED Medication Differ From Sildenafil or Tadalafil?

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What is Stendra (Avanafil)?

Stendra is the brand name of the latest PDE-5 erectile dysfunction medication on the market. Stendra was released in 2012, and is currently the newest PDE-5 ED medication available.

The PDE-5 medications function very similarly in the body, and work pretty well for most men experiencing erectile dysfunction. However, when diving into the nuances of these medications there are some slight differences that may help you or your doctor find the one that best suits you.

Below, we will look into some of the differences and similarities between Stendra and the two most common generic erectile dysfunction medications (Sildenafil and Tadalafil).

How is Stendra similar to Sildenafil or Tadalafil?

For these three medications, there are a lot of similarities. Below are a few of the most important things that make Stendra, Sildenafil, and Tadalafil alike for patients.

Class of medications:

All three of these medications are in the class of medications called PDE-5 inhibitors.

Mechanism of action:

The way these medications function in the body is also the same. PDE-5 inhibitors relax the smooth muscles in the penis and dilate vessels to improve local blood flow. Ultimately, these medications make it easier for men with ED to achieve and maintain an erection.

Side effects:

The reported side effects of these medications are also very similar. For Stendra, the most commonly reported side effects during clinical trials include headache, flushing, congestion, nasopharyngitis, and back pain. 

For Viagra (Brand name of Sildenafil), the most common side effects during clinical trials include headache, flushing, heartburn, abnormal vision, congestion, myalgia, back pain, nausea, dizziness, and rash. 

For Cialis (Brand name of Tadalafil), The most commonly reported side effects include headache, heartburn, back pain, myalgia, congestion, flushing, and pain in a limb.

As you can see above, there are many overlaps and commonalities between these three medications, which is what we would expect for medications in the same medicinal class.


All three medications are normally well-tolerated, and the vast majority of users do not need to stop using these medications due to severe, annoying, or problematic side effects.

How is Stendra different from Sildenafil or Tadalafil?

The small differences between these three medications are truly what set them apart and help doctors and patients choose one which is tailored to their schedule and lifestyle.

Time to start working:

The time that these medications take to start working is probably one of the biggest functional differences between the three. 

The Stendra onset of action may be as soon as 15 minutes after taking the tablet.

The Sildenafil onset of action may be 30-60 minutes after taking your dose.

And, the Tadalafil onset of action may be 15-45 minutes after taking your medication.

How long it lasts:

When discussing how long these medications last, it is important to note that this does not mean an erection will last for this long, just that the medication may make it easier for you to achieve and maintain an erection during this window of time after using the medication.

The ideal duration of action may be a personal preference, and some may opt for an ED medication that quickly gets out of your system in a few hours, or one that really sticks around -- maybe as long as 3 days.

The duration of action for Stendra is around 6 hours.

The duration of action for Sildenafil is about 12 hours.

And, the potential duration of action for Tadalafil is up to 36 hours.


If the affordability of medications is an issue, this may also be a big difference to consider between these medications.

Currently, Stendra is a brand-only medication, as a generic version has not yet been released. This means that the cost per tablet is much more expensive than a generic Sildenafil or generic Tadalafil tablet.

Both Sildenafil and Tadalafil are generic medications. Sildenafil is the generic version of the brand name medication, Viagra. And Tadalafil is the generic version of the brand name medication, Cialis. If you do decide that you want to stick with the brand-name medications, you will likely also encounter a higher price tag, although most users opt for the generic versions due to the significant cost savings.

Currently, in October 2021, the cash price for 6 Stendra tablets comes up to around $400.

This is compared to the generic Sildenafil or Tadalafil tablets which you can find at Strut Health for as low as $3 per dose.

Strut Health Sildenafil and Tadalafil ED medications prescribed online

Here at Strut Health, we try to make getting high-quality medical treatment for potentially sensitive situations easier for you. We also pride ourselves in having some of the most competitive and affordable prices available.

We offer Sildenafil (generic Viagra) and Tadalafil (generic Cialis) medications for men who are suffering from ED symptoms. 

If you are interested in seeing if Sildenafil or Tadalafil are a good fit for you, you can have a free online questionnaire-based telemedicine consultation with our U.S. licensed doctors today in about 10-15 minutes.

If you are a good candidate for ED treatment, your medication can be shipped to your front door with our free shipping.

If you have any questions or concerns during your treatment, our team and doctors are available for free unlimited follow-ups.

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