If you're exploring GLP-1 medications for weight loss or type 2 diabetes, you’ve probably come across oral semaglutide, or even better, sublingual semaglutide, or injectable options. Oral and sublingual options tend to be cheaper, and easier to take. So, where's the catch? Is oral semaglutide actually effective—or is it just the less powerful version of the shot?

Let’s clear this up.

The Short Answer: Yes, Oral Semaglutide Is Effective

Oral semaglutide has proven to be highly effective for weight loss, with participants in the OASIS 1 study losing an average of 15.1% of their body weight over 15 months. This is comparable to the results seen with injectable semaglutide, which also helps non-diabetic individuals achieve significant weight loss. Oral semaglutide may offer a powerful, needle-free alternative for those looking for easy and effective weight management.

Let’s explore what the latest research shows about oral semaglutide effectiveness.

Oral vs. Injectable Semaglutide: What the Research Says

A pivotal study, OASIS 1, sheds light on the effectiveness of oral semaglutide for weight loss in individuals without type 2 diabetes. 

Over the course of 15 months, participants taking oral semaglutide saw an impressive average weight loss of 15.1% of their body weight. In comparison, the placebo group experienced a modest 2.4% weight loss. 

Notably, 85% of participants taking oral semaglutide lost at least 5% of their body weight, with 34% losing 20% or more—figures that highlight the significant impact this oral formulation can have.

These results are comparable to those observed in injectable semaglutide, which is also known for its effectiveness in promoting weight loss. The injectable form of semaglutide has shown similar weight loss outcomes in non-diabetic individuals, further validating the effectiveness of both formulations for individuals looking to reduce body weight.

Key Oral Effectiveness Findings from OASIS 1 Study:

• 15mg of oral semaglutide resulted in a 15.1% average weight loss over 68 weeks.
  
  
• The placebo group lost 2.4% on average.
  
  
• 85% of participants lost at least 5% of their original weight.
  
  
• 34% lost 20% or more of their body weight.
  

Why Oral Semaglutide Absorption Matters (And How Dissolvable Oral Lozenges Help)

One of the known challenges with oral semaglutide is getting it into your bloodstream effectively, for some more than others. 

Unlike injectable versions that go straight in, oral medications have to survive your digestive system—and that means a portion of the active ingredient can get lost along the way.

That’s why absorption matters.

To solve this challenge and make oral options even more appealing, Strut’s innovative dissolvable oral semaglutide is delivered as a lozenge, not a traditional pill. 

This lets the medication absorb directly through the  tissues in your mouth—under the tongue (sublingual) and through the cheek (buccal)—bypassing much of the digestive process altogether.

The result? Likely better absorption, faster onset, and no need for needles, vials, or complicated routines.

It’s a smarter, simpler way to get the benefits of semaglutide—without the hassle.

Going Deeper: Stronger, Dual-Action GLP-1 Oral Options 

Some users find that to continue seeing weight loss results they might need higher doses and eventually more powerful GLP-1 options.

For those who need stronger GLP-1 support, Tirzepatide could be an excellent choice. Unlike traditional medications that target just one pathway, Tirzepatide activates two powerful receptors—GLP-1 and GIP—to help control blood sugar, curb appetite, and promote fat loss.

Tirzepatide troches, our innovative oral version, offers a gentler and more convenient alternative. These lozenges or tablets combine the potent dual-action benefits of Tirzepatide with the ease of an oral treatment. Ideal for those who need a more robust GLP-1 solution than oral semaglutide, Tirzepatide troches make it easier than ever to experience the powerful benefits of this advanced weight loss therapy—without the need for injections.

Summary: Is Oral Semaglutide Effective? 

Oral semaglutide may be an effective weight loss solution, especially for individuals who prefer a non-injection route. While injectable semaglutide may offer faster results, oral semaglutide provides a gentler approach with effective gradual weight loss, making it an excellent option for those who cannot tolerate injections or want to avoid them. 

Clinical studies show that oral semaglutide helps lower blood sugar and supports weight loss, though the effects may be more gradual compared to its injectable counterpart.

Ultimately, oral semaglutide may offer meaningful weight loss and health benefits for those who prefer an oral option over a needle. 

Start Your Journey with Strut Health: Convenient Oral Semaglutide Options Delivered to You 

At Strut Health, we offer compounded oral Semaglutide lozenges as well as injectable Semaglutide options, tailored to fit your unique needs.

Our simple online process connects you with a licensed healthcare provider for a free telehealth GLP-1 consultation to determine if Semaglutide is right for you. Once approved, your medication will be shipped directly from a trusted U.S. compounding pharmacy.

Need follow-ups or dosage adjustments? We provide unlimited support at no additional cost. Start your journey with Strut Health today, and experience personalized weight management care with the convenience you deserve.