Oral Sermorelin

Oral Sermorelin is a compounded sublingual formulation of a growth hormone-releasing hormone (GHRH) analogue that signals your pituitary gland to release natural growth hormone in your body's own physiological pulses, without injections.

Place the lozenge under your tongue and allow it to dissolve fully, typically in the evening to align with your natural overnight GH pulse. 30 lozenges are provided per month for daily use.

Synthetic HGH replaces growth hormone directly and overrides your body's feedback loop. Sermorelin signals your body to make its own GH, preserving the natural pulsatile pattern and reducing the risk of over-suppression.

Sermorelin may support mental clarity and focus, deeper and more restorative sleep, lean muscle development and recovery, and overall energy, all by working with your body's own growth hormone pathway.*

Both formats contain sermorelin. The oral lozenge dissolves under the tongue once daily with no needles, while the injectable is a subcutaneous injection taken 5 days on and 2 days off. The injectable may offer slightly higher bioavailability, but the lozenge is a needle-free alternative for patients who want to avoid injections.

Many patients notice improvements in sleep quality within the first weeks. Changes in energy, body composition, and recovery typically build over about 90 days of consistent dosing.

Sermorelin works by stimulating your own pituitary gland rather than replacing growth hormone directly, which preserves your body's natural feedback loop and may reduce the risk of over-suppression compared to synthetic HGH*. Your physician can help determine whether it's appropriate for you.

Share your full list of current medications and any other peptide therapies with your physician before starting. They can confirm whether combining Sermorelin with another peptide protocol is appropriate for you.

Most patients dose Sermorelin in the evening, on an empty stomach, to align with the body's natural overnight GH release.

Mild oral irritation, flushing, mild headache, brief dizziness, or sleepiness after dosing. Side effects typically resolve quickly.

The online consultation is included with your monthly price. You only pay for the medication if a Strut physician determines treatment is appropriate.

Keep your lozenges at room temperature as directed by the pharmacy label, protected from light and moisture. Ask your physician or pharmacist about specific storage guidance if you're traveling.