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What Is the Safest ED Medication?

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When you are looking at the various medications for a certain condition, it may be difficult to understand just what the differences are between them, and which one might be the best fit for you.

Most people will want to find a medication that works for them, has side effects that are tolerable, is affordably priced, and is considered relatively safe.

Below, we will cover if there are differences as far as safety goes for the most popular ED medications, review the potential side effects, and offer some advice on how to take your medications in the safest manner.

All PDE-5 inhibitor ED medications are considered relatively safe

PDE-5 inhibitors are the main class of erectile dysfunction medications. Some of them may be more familiar to you than others, but they all function about the same, and have very similar safety profiles. The most prominent difference between them as it applies to patients is likely the amount of time they continue working in your system.

The most common PDE-5 inhibitors are:

  • Sildenafil (brand name Viagra)
  • Tadalafil (brand name Cialis)
  • Vardenafil (brand name Levitra)
  • Avanafil (brand name Stendra)

All four of these medications are considered relatively safe and well-tolerated for most users when used as prescribed.

PDE-5 inhibitor ED medications have similar side effects

When most people are talking about the “safety” of the medication, they may also be talking about the potential risks of side effects and just how severe those side effects may be.

As with most medications, there are more common but less severe side effects that may be slightly annoying or irritating, but not bothersome enough to want to stop using the medication. It is also important to note that the exact same medication and strength will have no side effects for some people, but may have many for others. 

If any side effects are bothersome or severe, it is important to mention them to your doctor. Switching to a lower strength of the same medication or switching to another medication within the class may potentially change or reduce side effects.

The more common side effects that you may see for these medications tend to be about the same for all 4.

More common side effects with PDE-5 inhibitors include:

  • Headache
  • Nasal congestion
  • Flushing
  • Upset stomach
  • Nasopharyngitis
  • Vision changes
  • Back pain
  • Muscle pain

More severe side effects with PDE-5 inhibitors include:

  • Dizziness
  • A sudden drop in blood pressure
  • An erection lasting longer than 4 hours

An erection lasting longer than 4 hours is considered a medical emergency called priapism. Priapism requires immediate medical attention and has the potential to cause permanent damage to the penile tissue.

Using your PDE-5 medications as directed and sticking with the lowest dose that helps with your ED symptoms may help reduce your risk of side effects.

The safest way to use ED medications is to follow your doctor’s instructions

The question then is not really so much of which ED medication is the safest, as much of how can you take ED medications in the safest way possible.

The best way to keep ED medication usage safe is to use the medication exactly as described on your medication label and how it was instructed to you by your doctor.

Do not increase your strength by taking an extra tablet with each dose, and do not take additional doses in the same day. All PDE-5 inhibitors are approved for as-needed dosing, but no more than one dose per day. Even if you feel like the effects have “worn off” or aren’t working well enough for you, there will still be some amount of active drug in your system for at least 1 day. So, taking more in this time period can end up being too much and cause unwanted side effects or adverse events.

It may not be safe for certain people to take any ED medication

Another factor that may make ED medications less safe is if people that are not considered good candidates for PDE-5 inhibitors take them anyway.

All PDE-5 inhibitors are prescription only. But, unfortunately, there may be unsavory sources of these medications that people may try to source from. This can be especially dangerous as you will not have a doctor to review your health history and determine if these medications are safe for you.

People may not be a good candidate for PDE-5 ED medications if the following applies:

  • People who are not healthy enough for sexual activity
  • People with current or previous cardiovascular issues
  • People who use any form of nitrates
  • People who use certain interacting medications like alpha-blockers
  • People who have had a stroke
  • People with resting low or high blood pressure

What is the safest ED medication: Bottom Line

The safest ED medication is one that has been prescribed by a medical professional that has reviewed your full medical history and understands your current ED symptoms and treatment expectations.

Additionally, the safest ED medication is one that is used while abiding by the instructions from your doctor, pharmacy, and patient drug information.

While most people who are good candidates for PDE-5 inhibitor treatment tolerate these medications well, certain people who should not be using these medications may experience severe and dangerous effects from trying to use them anyway. Always listen to your doctor and pharmacist if they say these medications are not safe for you, and do not try to source or use them.

Strut Health Sildenafil and Tadalafil prescribed online for ED

Here at Strut, we try to make getting safe and effective ED treatment easier for appropriate patients.

We carry the two most popular ED medications, Sildenafil (generic Viagra) and Tadalafil (generic Cialis). To see if these medications may be a good fit for you, simply have a free online telemedicine questionnaire-based consultation in 10-15 minutes. A U.S. licensed physician will review your information and approve the medication if appropriate. Your prescription will then be put together at a U.S. licensed pharmacy and shipped to your front door with free shipping.

If you have any questions during your treatment, our team and doctors are available for free unlimited follow-ups to guide you through.

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