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Tretinoin For Wrinkles: What You Need To Know

What strength of tretinoin cream is best for wrinkles? Tretinoin usually comes in 3 strengths: 0.025%, 0.05%, and 0.1%. Learn what strength to use for wrinkles.

Read on

If you are into youthful skincare, then you know about Tretinoin.

Starting in your 20s or 30s, many start noticing fine lines and a lackluster skin appearance.

And while these skin changes are perfectly normal, if you would rather have them be less visible, there may be something you can do about it.

But, Tretinoin can be tricky - what strength is best, how do you use it, and where can you find it?

In this article, we are going to go over how Tretinoin for wrinkles is chosen for its efficiency, which strength to look for, how to use Tretinoin, and where to get some.

How does Tretinoin work for wrinkles?

Tretinoin helps increase the speed of cell turnover, meaning that the top few layers of skin are being renewed much faster than usual, leading to fewer fine lines and a fresher appearance.

By quickly sloughing off those photodamaged (sun-damaged) skin cells, Tretinoin helps reduce wrinkles, hyperpigmentation, and rough skin patches.

In addition, Tretinoin helps increase the production of collagen in the skin, the protein responsible for skin elasticity and bounce.

How well does Tretinoin work for wrinkles?

In one 16 week study, 15 patients applied Tretinoin cream to their face daily and 15 applied just a placebo cream. At the end of the 16 week period, none of the placebo group had facial benefits, where 14 out of 15 of the Tretinoin group had significant photoaging reduction.

A 1989 study had patients with photodamaged skin apply 0.05% Tretinoin cream once daily for 6 months. The study reported significant reductions in many of the signs of photodamage with minimal side effects.

Another study measured the amount of collagen present in sun-damaged skin tissue before and after 10-12 months of using a daily Tretinoin cream or a placebo cream. In the group using the placebo cream, skin collagen decreased by 14%, whereas in the Tretinoin treatment group skin collagen formation increased by 80%!


What strength of Tretinoin is best for wrinkles?

Tretinoin usually comes in 3 strengths - 0.025%, 0.05%, and 0.1%.

0.025% is the mildest strength and is usually used for general skin improvements or mild acne.

0.05% is seen most often for anti-aging preparations to reduce the appearance of fine lines.

0.1% has the most intense side effects but is often used for severe acne.

The increasing strengths generally come with increasing side effects such as: Dryness, Peeling, Itching, and Redness.

These side effects tend to subside after a few weeks of treatment.


How to use Tretinoin cream for wrinkles?

Tretinoin is most often used as a once-daily application, usually at night.

Wash your face with a gentle cleanser and allow the skin to fully dry, as remnants of water on the skin may increase the irritation side effects.

A small pea-sized amount is plenty and overuse of the cream may cause additional irritation.

Spread the cream over the entire face, avoiding the lips and too close to the eyes since these areas may become irritated.

Wash hands after application and leave the cream on overnight.

During Tretinoin treatment, be sure to wear a daily moisturizer and sunscreen, as Tretinoin can make your skin more dry and sensitive to the sun than usual.


Where to buy Tretinoin cream?

Tretinoin is a prescription-only medication, and cannot be found over the counter.

You can schedule a visit with your local doctor to discuss Tretinoin therapy.

Or, you can have an Online Questionnaire-based Telemedicine Consultation with our U.S. licensed doctors in under 10 minutes to see if Tretinoin treatment is the right course for you.

If you are a good candidate for our Anti-Aging, Acne Scar, or Acne Formulations containing Tretinoin, we can ship your prescription quickly and discreetly to your front door.


Tretinoin works for wrinkles by increases cell turnover and increases collagen production.

Many studies back up the photoaging benefits of a topical Tretinoin cream.

Tretinoin 0.05% is one of the most common strengths for its anti-aging benefits, although you will sometimes see 0.025% or 0.1%.

Increasing strengths of Tretinoin tend to come with increasing side effects.

Tretinoin is normally applied once daily at night to clean, dry skin.

Tretinoin therapy must be paired with daily sunscreen use as it can make your skin more sensitive to the sun.



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